18.4.2013, Michael Bischof

URL:
http://www.koek.naturaldyes.de/oral.sublingual.en.html



In the following text the aim is not consulting for a better, more efficient method how to apply drugs. It centers on how to improve the  uptake  of substances that are not easy made available (functionable).

The literature for such details is scarce, to my surprise. If in human medicine, in the literature about nutrition such studies are rare the question is where any milligramm, any mikrogramm really counts. This is the case with drugs, especially forbidden drugs. These have restricted access and are extreme expensive. Therefore interested people researched a lot for proper application methods. Any waste would be unaffordabe - there.
Source
In such a text, whose source I do not reveal, I read (translated from the English original, M.B.):

Oral versus sublingual

[...]
The median dosage is about 500 to 800 µg sublingual. In pharmacy sublingual (or buccal) means a form of application of medicaments through absorption via the mucosa... With sublingual uptake the substances move quicker into the blood circulation, as the venous blood moves directly from the mucosa to the upper vena cava.
Whereas with oral uptake the substance first has to pass the liver to enter the big blood circulation. Passing the liver means in most cases that it is chemically changed.

With sublingual uptake the liver is circumvented.
Die orale Einnahme von 2C-I-NBOMe soll dem Vernehmen nach deutlich weniger wirksam sein als die sublinguale. 2C-I-NBOMe kann auch nasal appliziert werden.
[...]
 

In case of Angina pectoris attacks the active ingredient nitroglycerine should work quick. It is applied by a capsule which is destroyed by the teeth. Immediately one has quite high concentration of it in the salivary and therefore a quick uptake into the blood circulation.

   Source(German)

 And all this means: to be sure to uptake substances that are difficult to dissolve in water one has to prepare them as a suitable mixture and should keep this mixture in the mouth as long as possible.

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