In the following text the aim is not consulting for a better, more
efficient method how to apply drugs. It centers on how to improve
the uptake of substances that are not easy made available
The literature for such details is scarce, to my surprise. If in human
medicine, in the literature about nutrition such studies are rare the
question is where any milligramm, any mikrogramm really counts. This is
the case with drugs, especially forbidden drugs. These have restricted
access and are extreme expensive. Therefore interested people
researched a lot for proper application methods. Any waste would be
unaffordabe - there.
In such a text, whose source I do not reveal, I read (translated from the English original, M.B.):
Oral versus sublingual
The median dosage is about 500 to 800 µg sublingual. In pharmacy sublingual (or buccal)
means a form of application of medicaments through absorption via the
mucosa... With sublingual uptake the substances move quicker into the
blood circulation, as the venous blood moves directly from the mucosa
to the upper vena cava.
Whereas with oral uptake the substance first has to pass the liver to
enter the big blood circulation. Passing the liver means in most cases
that it is chemically changed.
With sublingual uptake the liver is circumvented.
Die orale Einnahme von 2C-I-NBOMe soll dem Vernehmen nach deutlich
weniger wirksam sein als die sublinguale. 2C-I-NBOMe kann auch
nasal appliziert werden.
In case of Angina pectoris
attacks the active ingredient nitroglycerine should work quick. It is
applied by a capsule which is destroyed by the teeth. Immediately one
has quite high concentration of it in the salivary and therefore a
quick uptake into the blood circulation.
And all this means: to be
sure to uptake substances that are difficult to dissolve in water one
has to prepare them as a suitable mixture and should keep this mixture
in the mouth as long as possible.