URL of this page:  http://www.koek.naturaldyes.de/flavonoid.hippocampus.en.140112.html

12.1.2014, M.B.


Natural dye substances improve the brain
Ok, the unavoidable has happened. It became obvious what we know since long: that flavonoid compounds support the brain efficiency in a remarkable amount. Nautral dyes are health enhancers, of course.

This happens only with rats?

Come on, honestly: aren't we all rats? We have to remember  the fact that  bioavailability is the key factor when applying flavonoid compounds. This availability depends on how they are  processed and uptaken.
 


http://www.ncbi.nlm.nih.gov/pubmed/24333331


2013 Dec 11;79C:335-344. doi: 10.1016/j.neuropharm.2013.12.003. [Epub ahead of print]

A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats.

Rendeiro C1, Foley A2, Lau VC3, Ring R4, Rodriguez-Mateos A3, Vauzour D3, Williams CM5, Regan C6, Spencer JP7.

1Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK; School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK.
2Berand Neuropharmacology, NovaUCD, Belfield Innovation Park, UCD, Belfield, Dublin 4, Ireland.
3Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK.
4School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
5School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK.
6Berand Neuropharmacology, NovaUCD, Belfield Innovation Park, UCD, Belfield, Dublin 4, Ireland; School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
7Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK. Electronic address: j.p.e.spencer@reading.ac.uk.

Abstract

The increase in incidence and prevalence of neurodegenerative diseases highlights the need for a more comprehensive understanding of how food components may affect neural systems. In particular, flavonoids have been recognized as promising agents capable of influencing different aspects of synaptic plasticity resulting in improvements in memory and learning in both animals and humans. Our previous studies highlight the efficacy of flavonoids in reversing memory impairments in aged rats, yet little is known about the effects of these compounds in healthy animals, particularly with respect to the molecular mechanisms by which flavonoids might alter the underlying synaptic modifications responsible for behavioral changes. We demonstrate that a 3-week intervention with two dietary doses of flavonoids (Dose I: 8.7 mg/day and Dose II: 17.4 mg/day) facilitates spatial memory acquisition and consolidation (24 recall) (p < 0.05) in young healthy rats. We show for the first time that these behavioral improvements are linked to increased levels in the polysialylated form of the neural adhesion molecule (PSA-NCAM) in the dentate gyrus (DG) of the hippocampus, which is known to be required for the establishment of durable memories. We observed parallel increases in hippocampal NMDA receptors containing the NR2B subunit for both 8.7 mg/day (p < 0.05) and 17.4 mg/day (p < 0.001) doses, suggesting an enhancement of glutamate signaling following flavonoid intervention. This is further strengthened by the simultaneous modulation of hippocampal ERK/CREB/BDNF signaling and the activation of the Akt/mTOR/Arc pathway, which are crucial in inducing changes in the strength of hippocampal synaptic connections that underlie learning. Collectively, the present data supports a new role for PSA-NCAM and NMDA-NR2B receptor on flavonoid-induced improvements in learning and memory, contributing further to the growing body of evidence suggesting beneficial effects of flavonoids in cognition and brain health.

Copyright © 2013 Elsevier Ltd. All rights reserved.


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